名为“麻痹”的新型毒品席卷整座城市，吸食者药效上头时会陷入极度狂暴的状态，犯下大量无差别暴力案件，药效退去后则会陷入全身瘫痪。医院挤满了无辜受害者，民间义警也在街头大行私刑，整个城市彻底沦为暴力的温床

Isaac, and his wife, Tania, are heading to the countryside to help Isaac's estranged father Abe